![]() 6 Data showed that seizure risk was dose-dependent and highest in patients with eating disorders, previous head trauma, or epilepsy. The most significant side effect of bupropion is its risk of seizures.īupropion has been associated with seizures even at therapeutic doses and was removed from the market shortly after it was initially approved in 1986. Although often lumped with serotonergic SSRI antidepressants, it has limited serotonergic properties. 5 Unlike tricyclic antidepressants, bupropion is a monocyclic aminoketone and in a pharmaceutical class by itself. ![]() Bupropion is a unique antidepressant with FDA-approved indications for major depressive disorder 1-32, seasonal affective disorder 1,2, smoking cessation 4, and as an adjunct to diet and exercise for chronic weight management in adult patients with BMI >=30 kg/m2 when co-formulated with naltrexone.
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